Insulin Potentiation Therapy Low Dose for Cancer
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At the Arizona Center for Advanced Medicine, we can help those suffering
from cancer with holistic, comprehensive treatment that addresses every
angle of the disease.* At our Scottsdale integrative medical center, we
can offer you a full-range of medical support through this difficult time.
Learn more about the different approaches we take to helping patients recover
from cancer, or
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Understanding Insulin Potentiation Therapy (IPT) Low Dose for Cancer
A targeted approach using low-dose chemo and complementary therapies to
both defeat cancer and rebuild the immune system.*
The conventional treatment for cancer is the familiar trio of chemotherapy,
radiation, and surgery. The subsequent devastation to the immune system
and the organs - especially the liver and heart - is significant. The
reduced quality of life, including losing one's hair, vomiting, diarrhea,
mouth ulcers, low white count, susceptibility to infection, damage to
the immune system, etc. is also pretty hard to take.
In conventional treatment, chemotherapy drugs must be administered in doses
high enough to kill a large number of cancer cells without killing the
body's immune system and intestinal tract. It's a balancing act.
Patients are given as much chemotherapy as their body can tolerate. It
is like killing flies with a cannonball instead of fly swatter. You get
rid of some flies, yes, but you have a lot of collateral damage. Good
cells die along with the bad. Over time (and sometimes a fairly short
period of time, days rather than weeks), this massive bombardment can
lead to extremely low blood counts, organ failure, and death. Because
an already poorly functioning immune system is subjected to radiation
and toxic drugs, it is difficult to deliver a "cure."
A time-tested, modified form of chemotherapy has been used successfully
and safely around the world for more than 70 years. It is called IPTLDSM,
or Insulin Potentiation Therapy Low Dose.
IPTLD™ uses between 10 and 25% of the dosage of a conventional chemotherapy
regime. It provides a safer, much gentler alternative to conventional
chemotherapy, without the harsh side effects.* When combined with complementary
therapies to nurture the body, it is also more effective. It is a smart
way to approach cancer based on what makes cancer cells vulnerable.
Sugar & Cancer
There is a key difference between cancer cells and healthy cells: cancer
cells run exclusively on sugar and glutamine, the amino acid found in
high concentration in animal proteins. Cancer cells have a ravenous need
to consume the glucose (sugar) found in the blood stream. Glucose is their
unique source of energy, and because of the relatively inefficient way
cancer cells burn this fuel, they use up a great deal of it. This is why
cancer patients lose so much weight. Because cancer cells require so much
glucose, they virtually steal it away from the body's normal cells,
thus starving them.
To help sugar get inside the cancer cells, they are equipped with 10-16
times as many insulin receptors as healthy cells.[2,3] Insulin manages
the delivery of glucose across cell membranes into the cells. Put another
way, insulin escorts glucose through the cell membrane, into the interior
where the glucose provides energy to keep the cell alive.
If you have had a PET scan, you have seen this connection between sugar
and cancer cells at work. A PET scan is performed by injecting a radioactive
agent attached to a glucose molecule into a vein. The cancer cells, always
ravenous for sugar, take up the glucose much faster than healthy cells.
The radioactive agent gets into the cell along with the glucose. Bingo
- the scan produces a three-dimensional picture of a cancerous mass.
Call our Scottsdale integrative medical center at (480) 418-0220 to learn
more about how we can help.
Targeted Therapy for Cancer
Now, what would happen if, in addition to glucose, you add a little bit
of chemotherapy to the mixture? Bingo - the chemotherapy drugs are dragged
in to the cancer cells along with that glucose that they so crave. The
healthy cells are not bombarded. This is why patients undergoing IPT do
not experience the severe side effects of conventional therapy. Generally,
IPT patients do not go bald, nor do they experience severe nausea or organ damage.
The word "potentiate" means to make stronger or more effective.
In this case, it means that insulin makes the chemotherapy more effective.
A 1981 study conducted at George Washington University showed that when
the chemotherapy drug, methotrexate, is combined with insulin, the drug's
cell-killing effect increased by a factor of 10,000. Because insulin
enhances the effectiveness of the drugs, IPT uses only 10% to 25% of standard
dose drugs. There is no need to overwhelm a patient with large quantities
of drugs in the hope that the drugs will kill the cancer before they kill
the patient's immune system.
There is a second way that insulin helps us defeat cancer. Insulin stimulates
cells to grow, which they do by dividing. Cancer cells are most vulnerable
to many chemotherapeutic agents when they are dividing. With IPT, we
use insulin's stimulating properties to catch more cancer cells in
the process of dividing, so more of the drugs are absorbed than if division
had not been encouraged.
A third way insulin helps is with detoxification. Insulin increases "cellular
permeability." Glucose goes in easier, and the low dose chemo goes
in easier. The door swings both ways - toxins and debris from dying tumor
cells also pass out much easier. Insulin facilitates the detoxification
so necessary with cancer.
There is universal agreement that cancer is a failure of the immune system.
We feel strongly that "killing the cancer" is only one part
of the job. Re-training and strengthening the immune system is another
part of our job. Our patients continue to thrive and often end up with
a healthier immune system than when they started treatment.*
We use complementary therapies to nourish the body and protect the organs,
to create a more robust immune system and incidentally to create a hostile
inner terrain for cancer.*
As a tumor grows, the body may acclimate to the presence of abnormal cell
growth, fooling the brain into accepting the cancer as a normal presence
in the system. After the tumor is removed, the body may still respond
as if it were still present, much like an amputee's "phantom
One school of thought maintains that the brain sends messages that support
re-growth of tumors. Another school of thought teaches that each organ
system reflects particular emotions, both positive and negative. When
illness strikes, generally the cause originates in the mental or emotional
sphere, and manifests in that part of the body which is most vulnerable.
So, for instance, if we have been sexually abused as children, we may very
likely develop cancer of the female organs. If we see ourselves as powerless,
we may well develop cancer of the pancreas. If we are full of fear, bladder
or kidney cancer is often the end result.
It's not that we intend to become ill, not at all. But our bodies will
hold the messages of those experiences that we are too small or too powerless
to deal with. We hold those messages in the form of neurotransmitters,
second messengers, inflammatory markers, muscle tension, and habitual
responses to situations. If our parents were alcoholic, we tend to marry
alcoholics. If our parents beat us, or put us down all the time, we tend
to marry people who also beat us and denigrate us.
That does not mean that we cannot change our attitude. But first, we have
to see our attitude for what it is.
Other Forms of Treatment for Cancer
- Acupuncture has been used successfully to retrain the body's immune
system to defeat cancer, and correct or erase faulty body signals conducive
- Oxygen defeats cancer on a fundamental level. Some 75 years ago, Dr. Otto
Warburg was awarded two Nobel prizes for demonstrating that cancer occurs
when cells weaken due to lack of oxygen. According to Dr. Warburg,
that weakness causes the environment to become more acidic - a perfect
environment for the growth of pathogens and cancer. When we increase the
amount of oxygen in the tissues by using a hyperbaric oxygen chamber,
or simply by breathing oxygen-enriched air, we make the environment inside
our bodies much less friendly to cancer cells. Advanced cancer patients
can be 1000 times more acidic than a healthy person. One way to make low-dose
chemotherapy more effective is to insure that cancer cells are adequately
oxygenated and not acidic.
- Therapeutic doses of vitamin C, administered intravenously, have been proven
to defeat cancer cells. The National Institutes of Health confirmed in
2005 that vitamin C is selectively toxic to cancer cells and that tumor-toxic
levels of vitamin C can be attained using intravenous administration.
- Poly-MVA, or lipoic acid palladium complex, helps to regenerate damaged
mitochondria, thus restoring pre-cancerous cells to the normal oxidative
metabolism, while enhancing peroxide-induced damage to cancerous cells
through the generation of peroxides and other stress molecules which cancerous
cells cannot tolerate.
- We also make use of anti-oxidants like glutathione, various herbs and botanical
preparations, coffee enemas, and chelation. Special attention is paid
to nourishing the liver, the key organ for that all-important job of detoxification.
How Infrared Saunas Can Treat Cancer
Infrared saunas offer another approach to defeat cancer, through the use
of elevated body temperature. When fighting pathogens, the body sometimes
creates a fever to raise the internal temperature to kill unwanted cells.
We use the same principle with infrared saunas. Also, saunas are a great
way to detoxify. As a tumor shrinks, it sheds a large quantity of debris.
Saunas assist the body's efforts to move out the toxins through the sweat.*
The Photon Genius is a form of infrared sauna which not only uses heat
- like a regular sauna - but also coherent light frequencies, to restore
a sense of order to the cells of the body, as the light is carried around
by our own red blood cells.
Nutritional Therapy for Cancer Patients
At our Scottsdale alternative cancer treatment center, we use nutritional
therapy with all our patients. The cornerstone is a low glycemic diet
- very low sugar loads, no refined foods, nothing in a box, nothing with
chemicals or colorings in it. And you would be surprised how much of the
supermarket is devoted to things with chemicals and colorings. Take a
look at the snack and cracker aisle some time. We also use anti-angiogenic
therapy - largely through diet, consumption of those foods which heal
the blood vessel walls and decrease their responsiveness to the siren
calls of tiny tumors for more blood.[10,11] All our patients are encouraged
(and taught) to do vegetable juicing every day. We help them learn how
to cook, if necessary.* After all, how many people have been on a gluten-free
diet for 20 years? Certainly not most of those who come to our office.
An important part of the therapy involves fasting, to promote starvation
responses in the tumor cells. Since normal cells have a protective mechanism
that shuts down their metabolism when fuel is scarce, they are protected
when food is in short supply. Fasting the day before chemotherapy
is highly recommended, and fasting for at least 8-10 hours before IPTLDSM
therapy is required at the Arizona Center for Advanced Medicine.
After administering IPT, along with vitamins, herbs, immune enhancers,
and chelation, repeat testing 4-6 weeks later will often show that the
cancer has regressed, or even disappeared.
IPT's Positive Impact on Cachexia
The culprit behind perhaps half the cancer deaths is a wasting syndrome
called cachexia (pronounced "ka-kek-see-ah"). Patients lose
weight and literally starve to death.
Because cancer cells need even more energy than regular cells, the cancer
cells gobble up the incoming nutrition first. Your healthy cells get what
is left over which can mean the rest of your cells starve when conventional
treatment leaves you too nauseated to eat. The tumor stays strong, but
the patient wastes away.
The hypoglycemic pulse that occurs with the administration of insulin actually
helps the body assimilate the nutrition in food - vitamins, minerals,
and enzymes. Because IPT is a gentler approach, patients do not get the
severe bouts of nausea so common with conventional chemotherapy due to
destruction of the rapidly dividing and always renewed cells lining the
The Cellular Genetics Test for Cancer Patients
Which chemo drugs shall we use? Which complementary therapies are right for you?
Unlike conventional chemotherapy treatment, IPTLD™ is not a one-size-fits-all
approach. You are unique, and your response to various drugs and complementary
therapies is not necessarily the same as the next person's.
Think back to a time when you had a bladder infection. The lab tested your
urine sample against different antibiotics to find out which ones were
most effective at killing the bacteria. We use the same concept when choosing
therapies for chemotherapy.
We take a sample of your blood (and a fresh tissue sample, if available)
and test it against the chemo drugs and the various complementary therapies
to find out what will be most effective for you. We also look at the genetic
makeup of your individual tumor. When we custom tailor your therapy, you
have a better result.*
We use a laboratory which does the actual cell cultures in Greece, although
it has branches all over the world. The test is not inexpensive, and insurance
usually does not pay for this test. But we strongly feel it is the best
money you will ever spend. We include this test in our charges for the
initial 8 weeks of treatment.
The RESEARCH GENETIC CANCER CENTRE LTD is headed by Dr. Ioannis Papasotiriou,
an oncologist. He has developed a way of isolating circulating tumor cells
from peripheral blood, growing them in cell culture, and testing them
for chemosensitivity, as well as sensitivity to alternative/biological/botanical agents.
Only a few populations of tumor cells actually develop the ability to invade
other tissues and create metastatic spread of tumor. These cells are known
as circulating tumor cells (CTCs) and many of them are cancer stem cells.
The RGCC test isolates and measures these cells, then grows them in such
a way that they do not mutate during the growth process. The cells can
then be tested against various chemotherapeutic agents, as well as many
Also, metastatic cancer cells can vary genetically from the primary tumor.
At least two studies with breast cancer patients have demonstrated that
CTC can be HER2 positive while the primary breast tumor can be HER2 negative.[14,15]
Another study with prostate cancer demonstrated the same phenomenon. 
A landmark study published in the New England Journal of Medicine in 2007
compared women with lymph node-positive breast cancer who received the
standard trio of chemotherapy drugs - Adriamycin®, Cytoxan®, and
Taxol® (called ACT) to women who did not receive any chemotherapy.
Their HER2 status was also determined - the genetic characteristic of
the cancer. Researchers discovered that women who were HER2 negative and
estrogen receptor positive did not benefit at all from taking Taxol®.
Because approximately two thirds of women with breast cancer fall into
this category, the ramifications of this study are immense. So much for
the ineffectiveness of the one-size-fits-all approach to cancer.
A study published in the Journal of the National Cancer Institute in 2008
measured the effectiveness of an anthracycline-based chemotherapy regimen
in 5,354 women with early-stage breast cancer. Anthracyclines are a class
of chemotherapy drugs of which Adriamycin® is a key member. Scientists
determined that women with early-stage breast cancer who were HER2 negative
derived absolutely no benefit from taking Adriamycin® or other anthracycline
drugs. Given that approximately 80% of breast cancers are HER2 negative,
then only 1 out of 5 women with breast cancer can benefit from these drugs
that have considerable toxicity associated with their use. In another
study, 7% of patients treated with Adriamycin® developed congestive
heart failure. They apparently did not have Poly-MVA available to them.
Frequency of Cancer Treatments
With standard chemotherapy, treatments are often spaced several weeks apart,
to allow the body to recover from the harsh effects of the treatment.
Since the standard dose chemotherapy attacks all rapidly dividing cells,
almost every patient experiences hair loss, and frequently they develop
diarrhea and intestinal tract ulcerations as well. Treatment is often
limited by the number and severity of the "side effects" which
the patient experiences. In addition, the length of time between treatments
allows the tumor cells which were not killed initially to continue growing.
Sometimes the cells not killed become resistant to the chemotherapeutic
agent which was used, and by spacing the treatments so far apart (in order
to protect the life of the patient) the resistant population of cells
is allowed to take over.
IPTLDSM is a more enlightened paradigm which tailors treatment towards
the individual uniqueness of your body and your cancer. With IPT therapy,
we generally start with low-dose chemotherapy agents twice a week for
the couple of weeks. The frequency may then be reduced to once a week,
and eventually to once every 2-3 months, until there is no further sign
of cancer cells in the blood, and the tumor is no longer visible by conventional
means. Chemotherapy agents are interspersed with complementary therapies.
So on Monday, for example, you may receive chemotherapy agents and on
Wednesday, you may receive intravenous vitamin C.
How to Begin
We encourage you to request an orientation with our Scottsdale alternative
cancer treatment center so you can make an educated decision. There is
no charge for this. Come meet the doctors and staff, and tour the clinic.
Meet other patients. The course of action you choose is a significant
commitment, and one that will impact those around you. Feel free to bring
family to the orientation. Ask every question that is on your mind.
For your first appointment (after the orientation visit), plan to spend
two hours with us. Bring all your medical records and test results. We
will ask you to fill out a history form ahead of time so you can do that
at home where you have access to information about prior vaccinations,
surgeries, mercury fillings and root canals, major emotional traumas you
have experienced in life, etc.
We have an integrative cancer therapy program that provides an approach
for the short and the long term - the treatment is tough enough to defeat
cancer in the short term, yet leave your body nourished and empowered
to ward off cancer on its own in the long term so the cancer does not return.*
"Nothing in life is to be feared. It is only to be understood."
- Marie Curie, awarded Nobel Prizes in physics and chemistry
See more of our articles regarding cancer here.
*Disclaimer: There is no guarantee of successes for any given medical treatment.
Each individual is unique and may respond differently to our medical services,
meaning results may vary for each person.
 Morgan G, Ward R et al.
The contribution of cytotoxic chemotherapy to 5-year survival in adult
malignancies. Clin Oncol (R Coll Radiol). 2004 Dec;16(8):549-60.
 Milazzo G, Giorgina F, Belfiore A et al.
Insulin Receptor Expression and Function in Human Breast Cancer Cell Lines. CANCER RESEARCH 52, 3924-3930, July 15, 1992
 Belfiore A, Malaguarnera R.
Insulin receptor and cancer. Endocr Relat Cancer. 2011 Jul 4;18(4):R125-47. doi: 10.1530/ERC-11-0074.
 Alabaster, A; Vonderhaar, B; Shafie S.
Metabolic modification by insulin enhances methotrexate cytotoxicity in
MCF-7 human breast cancer cells. Eur J Cancer Clin Oncol. 17:1223-1228
 Scavo LM, Karas et al.
Insulin-Like Growth Factor-I Stimulates Both Cell Growth and Lipogenesis
during Differentiation of Human Mesenchymal Stem Cells into Adipocytes. J Clin Endocrin Metab 89;7:3542-3552.
 Litsey T.
Acupuncture vs. Cancer: Re-Engaging the Body's Immune System . AcupunctureToday. October, 2003, Vol. 04, Issue 10
http://mosao2.org/Article%20-%20Medicine/cancer_Otto_Warburg_00.pdf Downloaded 02-24-13.
 Chen Q, Espey MG, Krishna MC, Mitchell JB, Corpe CP, Buettner GR, Shacter
E, Levine M.
Pharmacologic ascorbic acid concentrations selectively kill cancer cells:
action as a pro-drug to deliver hydrogen peroxide to tissues. Proc Natl Acad SciU S A. 2005 Sep 20; 102(38):13604-9.
 Sudheesh NP, Ajith TA, Janardhanan KK, Krishnan CV.
Effect of POLY-MVA, a palladium alpha-lipoic acid complex formulation against
declined mitochondrial antioxidant status in the myocardium of aged rats. Food Chem Toxicol. 2010 Jul;48(7):1858-62. doi: 10.1016/j.fct.2010.04.022.
 Li WW, Li VW, Hutnik M, Chiou AS.
Tumor angiogenesis as a target for dietary cancer prevention. J Oncol. 2012;2012:879623. doi: 10.1155/2012/879623.
 Arulselvan P, Wen CC, Lan CW, Chen YH, Wei WC, Yang NS.
Dietary administration of scallion extract effectively inhibits colorectal
tumor growth: cellular and molecular mechanisms in mice. PLoS One. 2012;7(9):e44658.
 Lee C, Longo VD.
Fasting vs dietary restriction in cellular protection and cancer treatment:
from model organisms to patients. Oncogene. 2011 Jul 28;30(30):3305-16. doi: 10.1038/onc.2011.91.
[13 Apostolou P, Toloudi M, Chatziioannou M, Ioannou E, Papasotiriou I.
Cancer stem cells stemness transcription factors expression correlates
with breast cancer disease stage. Curr Stem Cell Res Ther. 2012 Nov;7(6):415-9.
 S Meng, D Tripathy, et al;
HER-2 gene amplification can be acquired as breast cancer progresses. Proc Natl Acad Sci U S A. June 22, 2004;101(25):9393-8.
 P. Wülfing, J Borchard, et al;
HER2-positive circulating tumor cells indicate poor clinical outcome in
stage I to III breast cancer patients. Clin Cancer Res. March 15, 2006;12(6):1715-20.
 CA Olsson, GM De Vries, et al;
The use of RT-PCR for prostate-specific antigen assay to predict potential
surgical failures before radical prostatectomy: molecular staging of prostate cancer. Br J Urol. March 7, 1996;7(3):411-7.
 DF Hayes, AD Thor, et al;
Cancer and Leukemia Group B (CALGB) Investigators. HER2 and response to
paclitaxel in node-positive breast cance r. New England Journal of Medicine, October 11, 2007;357(15):1496-506.
 A Gennari, MP Sormani ,et al;
HER2 status and efficacy of adjuvant anthracyclines in early breast cancer:
a pooled analysis of randomized trials. J Natl Cancer Inst. January 2, 2008; 100(1):14-20.
 SM Swain, FS Whaley, MS Ewer;
Congestive heart failure in patients treated with doxorubicin: a retrospective
analysis of three trials. Cancer. June 1, 2003; 97(11):2869-79.